What is Ewing's sarcoma??

 What is Ewing's sarcoma??

-What Is Bone Cancer?

-Know the Symptoms or Signs of bone cancer?
-Handling and treatment of bone cancerPrevention of Bone
-CancerTypes of bone cancer.

What is Ewing's sarcoma??
Ewing sarcoma is a malignant tumor of the second largest after osteosarcoma. These tumors are composed of round cells, which occur frequently in the software the first three decades of life. Most are located in long bones, although various other bones may also be involved. Diagnosis can be established by anamnesis, physical examination, investigation procedures both invasive and non invasive.
Ewing sarcoma is very fierce with low cure rate even with good ablative surgery with radiation or not. However, radiation therapy in the primary and regional metastases combined with chemotherapy using doxorubicine, cyclophosphamide, vincristine and dactynomycin been reported to increase patient survival even with metastases. Indeed multimodalitas therapy thought to increase the proportion of long-term disease-free survival of approximately 15% to more than 50% in 2-3 decades.

Definition of Ewing's sarcoma 
Ewing sarcoma is a malignant tumor composed of round cells, small of the most common in the first three decades of life. Ewing's Sarcoma is a primary malignant tumor most often about the long bones, mostly in diafisis. The most commonly affected bones are the pelvis and ribs.

Ewing sarcoma is a malignant neoplasm that grows fast and derived from primitive cells of the bone marrow in young adults .

The incidence of Ewing's sarcoma
These tumors most often seen in children in their teens and most often are the bones panjang.Pada children, Ewing's sarcoma is a tumor of the most common primary bone after osteosarcoma. Every year no less than 0.2 cases per 100,000 children in the diagnosis of a sarcoma Ewing, and estimated there were 160 new cases that occurred in 1993.Around the world, the incidence varies from areas with high incidence, such as the United States and Europe to regions with low incidence, such as Africa and China. Ewing sarcoma often occurs in the second decade of life. Rarely occurs at age 5 years and after 30 years. Incidence is equal between men and women. Ewing sarcoma is usually not associated with congenital syndromes, but many associated with skeletal anomalies, for example: enchondroma, aneurysm bone cysts and urogenital anomalies, eg hypospadias.

There are several risk factors that influence the incidence of Ewing's sarcoma, namely: 

1). The age factor. The incidence of Ewing's sarcoma to increase rapidly from near 0 at age 5 years and peaked at age 10 -18 years. After age 20 years the incidence decreased again and approached 0 at the age of 30 years.

2). Gender factor. Men slightly higher risk than women, but after age 13 years the incidence between men and women is almost the same.

3). Factor of race. The disease is rarely found in blacks.

4). Genetic factors, which are known include:

a). Family history. Risk factors in the first lineage was not increased. There is no syndrome families associated with Ewing sarcoma.
b). Genetic anomalies, presence of anomalies on chromosome 22, chromosome translocations or loss was detected in 85% of patients with Ewing sarcoma.c). History of bone disease, certain congenital anomalies of skeletal, namely aneurysm bone cysts and enchondroma increase the risk of Ewing's sarcoma, as well as genitourinary anomalies such as hypospadias and duplikasinya also associated with Ewing sarcoma.

Pathophysiology and Histology of Ewing's sarcoma 
A. PathophysiologyAccording to Ackerman's: types of commonly used grading system seems less important than the map of regional protocols and histologic evaluation. With the light microscope, Ewing's sarcoma appears as a mass difuse of homogeneous tumor cells. Often there is a biphasic population of cells with large, light and small, dark. Signs vascularization and extensive coagulation necrosis is a typical picture. Tumors will infiltrate the bone and make minor destruction. Edge is usually infiltrative tumor with Fili patterns and processes such as the finger of a compact with the basophil cells which are closely related to poor patient survival.

See Also,

A. Osteosarcoma 

B. Chondrosarcoma

C. Fibrosarcoma 

D. Chordoma

E. CancerBone

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Posted in: Bone Cancer,Cancer